When trying to load a file a window pops up allowing you to search and select your file, durin this phase any key pressed will enact the corresponding hotkey. This forces accidental changing of UI settings which should not happen since the users clear intent is to search for said file.
To fix: disable global hotkeys whiles the pop-up window is open. Normal behaviour of UI should resume once the user has selected desired file or cancelled/closed said window.
by Amak